1 Result for "

Lithospermum erythrorhizon Sieb. et Zucc.

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Lithospermum erythrorhizon Sieb. et Zucc." in MCE Product Catalog:

1
β,β-Dimethylacrylshikonin
β,β-Dimethylacrylshikonin
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Art. -Nr.: HY-N5112B
CAS. Nr.: 24502-79-2
Synonyms: Isoarnebin I
Category:  

Quinones Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Apoptosis Notch NO Synthase Bcl-2 Family

β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .
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